| Andreafsky Wilderness | |
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IUCN Category Ib (Wilderness Area)
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| Location | Wade Hampton / Nome Census Areas, Alaska, USA |
| Nearest city | St. Mary's, Alaska |
| Area | 1,300,000 acres (5,260.91 km2) |
| Established | 1980 |
| Governing body | US Fish and Wildlife Service |
Andreafsky Wilderness is a wilderness area in the U.S. state of Alaska. Located within the Yukon Delta National Wildlife Refuge, it is about 1,300,000 acres (5,300 km2) in area, and was designated by the United States Congress in 1980.